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Can nicotine impact memory?

Volunteers sought for study of nicotine’s impact on memory

December 30, 2018
Amy H. Peterson - Staff Writer ( , Estherville News

An Iowa doctor is researching whether nicotine might improve mental acuity in people aged 55 and older who have memory loss.

Dr. Paul Newhouse is leading a study called the MIND study: Memory Improvement through Nicotine Dosing. He's looking for volunteers for the study.

"We're looking for adults, 55 and older who are nonsmokers, who identify themselves or have a family member identify them as having memory loss," Dr. Newhouse says.

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Contrary to popular belief, Dr. Newhouse says memory loss is not a normal part of aging and can be a precursor to Alzheimer's disease. Up to 20 volunteers from Iowa are needed to take part in the study, which would be conducted at the University of Iowa Hospitals and Clinics in Iowa City.

"They would be tested to see whether they have memory loss and then, if they are appropriate for the study, they would come back every three months or so to be seen," Newhouse says. "They would get tested periodically, they would get medically evaluated, so a very close follow-up."

While there is no payment for volunteering, there would be free treatment for up to two years and those who need it could be compensated for travel. Because nicotine is in tobacco products, most people think it's addictive and harmful, but Newhouse says that's not the case when it's used in a transdermal patch.

"If we separate nicotine from inhaling, like in smoking or vaping, then we really lose the addictive properties of nicotine, so it really doesn't seem to be habit-forming," Newhouse says. "We know that nicotine, if it's not inhaled, really seems to be much, much safer."

Nicotine is a natural plant product, he says, and it's safe when used as directed. Nicotine has medicinal benefits, according to Newhouse, and while it's usually associated with tobacco, it's also in tomatoes, eggplant and cauliflower.

Newhouse is director of the Center for Cognitive Medicine in the Department of Psychiatry at Vanderbilt University Medical Center in Nashville, Tennessee. The study is underway at 32 sites nationwide though this will be its first trial in Iowa. For more information, call 866-MIND-150 or visit:



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